SCHEMBL6621779

SCHEMBL6621779

CCN(Cc1ccccc1)c1ccc(Br)cc1.CCN(Cc1ccccc1)c1ccccc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.79
CNR2 P34972 5/20 0.61
NR1H2 P55055 1/20 0.55
NR1H3 Q13133 1/20 0.55
CYP2C19 P33261 1/20 0.55
MAPK1 P28482 3/20 0.50
KDM4E B2RXH2 2/20 0.50
ALDH1A1 P00352 2/20 0.50
LMNA P02545 2/20 0.50
MAPT P10636 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
MITF O75030 1/20 0.50
HPGD P15428 1/20 0.50
RAD52 P43351 1/20 0.50
KMT2A Q03164 1/20 0.50
L3MBTL1 Q9Y468 2/20 0.46
HTT P42858 1/20 0.46
TRPM5 Q9NZQ8 1/20 0.46
ESRRG P62508 1/20 0.45
CNR1 P21554 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5789341 0.98 TSHR (0.75) TSHRCNR2NR1H2NR1H3CYP2C19
SCHEMBL179996 0.89 TSHR (1.00) TSHRCNR2NR1H2NR1H3CYP2C19
Bromide SCHEMBL27967621 0.87 TSHR (0.96) TSHRCNR2NR1H2NR1H3CYP2C19
SCHEMBL2586563 0.87 CYP2C19 (0.64) TSHRCNR2NR1H2NR1H3CYP2C19
Hydrochloric Acid SCHEMBL3672654 0.87 TSHR (0.96) TSHRCNR2NR1H2NR1H3CYP2C19
SCHEMBL4407628 0.85 TSHR (0.91) TSHRCNR2NR1H2NR1H3CYP2C19
SCHEMBL17460822 0.83 TSHR (0.81) TSHRCNR2NR1H2NR1H3CYP2C19
SCHEMBL11682124 0.83 TSHR (0.68) TSHRCNR2NR1H2NR1H3CYP2C19
SCHEMBL11164170 0.83 TSHR (0.68) TSHRCNR2NR1H2NR1H3CYP2C19
SCHEMBL11794806 0.83 TSHR (0.55) TSHRCNR2NR1H2NR1H3CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212327-B8 PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS ABBOTT GMBH & CO KG (DE) 2004-02-25 EP disclosed
EP-1212327-A2 PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS BASF AKTIENGESELLSCHAFT (DE) 2002-06-12 EP disclosed
WO-2001019829-A2 PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS BASF AKTIENGESELLSCHAFT (DE) 2001-03-22 WO disclosed