Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.75 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4863522 | 0.86 | MAPK14 (1.00) | MAPK14MAPK11 | |
| SCHEMBL4860372 | 0.85 | MAPK14 (0.79) | MAPK14MAPK11 | |
| SCHEMBL6605403 | 0.83 | MAPK14 (0.67) | MAPK14MAPK11 | |
| SCHEMBL6601878 | 0.83 | MAPK14 (0.73) | MAPK14MAPK11 | |
| SCHEMBL6605924 | 0.83 | MAPK14 (0.83) | MAPK14MAPK11 | |
| SCHEMBL4855057 | 0.82 | MAPK14 (0.75) | MAPK14MAPK11 | |
| SCHEMBL4855124 | 0.82 | MAPK14 (0.85) | MAPK14MAPK11 | |
| SCHEMBL4862229 | 0.82 | MAPK14 (0.80) | MAPK14MAPK11 | |
| SCHEMBL4863092 | 0.82 | MAPK14 (0.74) | MAPK14MAPK11 | |
| SCHEMBL6604940 | 0.81 | MAPK14 (0.73) | MAPK14MAPK11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436269-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033482-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |