Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 12/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618406 | 0.92 | FGFR4 (0.60) | FGFR4LCKMAPK14FGFR1ABL1 | |
| SCHEMBL6619414 | 0.86 | FGFR4 (0.53) | FGFR4LCKMAPK14FGFR1TNK2 | |
| SCHEMBL6622100 | 0.84 | LCK (0.81) | FGFR4LCKMAPK14FGFR1ABL1 | |
| SCHEMBL6619141 | 0.83 | FGFR4 (0.57) | FGFR4LCKMAPK14FGFR1TNK2 | |
| SCHEMBL6621690 | 0.83 | FGFR4 (0.54) | FGFR4LCKMAPK14FGFR1TNK2 | |
| SCHEMBL6622839 | 0.80 | FGFR4 (0.56) | FGFR4LCKMAPK14FGFR1ABL1 | |
| SCHEMBL6622549 | 0.80 | LCK (0.69) | FGFR4LCKMAPK14FGFR1ABL1 | |
| SCHEMBL6620252 | 0.79 | MAPK14 (0.66) | FGFR4LCKMAPK14FGFR1ABL1 | |
| SCHEMBL16072330 | 0.79 | FGFR4 (0.71) | FGFR4LCKMAPK14FGFR1ABL1 | |
| SCHEMBL6620308 | 0.78 | LCK (0.56) | FGFR4LCKMAPK14FGFR1SIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123295-B1 | BICYCLIC NITROGEN HETEROCYCLES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| EP-1123295-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-16 | — | — | EP | disclosed |
| US-6150373-A | AMINO-SUBSTITUTED DIHYDROPYRIMIDO(4,5-D)PYRIMIDINONE DERIVATIVES; INHIBITORS OF THE T-CELL TYROSINE KINASE P56LCK; IMMUNOSUPPRESSANTS; ANTIINFLAMMATORY/-CARCINOGENIC AGENTS; BRONCHOPULMONARY, DERMATOLOGICAL AND CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |
| WO-2000024744-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-04 | — | — | WO | disclosed |