Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6907648 | 0.76 | KDM4E (0.63) | KDM4EHTTMAPTHSD17B10TP53 | |
| SCHEMBL29368738 | 0.76 | KDM4E (0.63) | KDM4EHTTMAPTHSD17B10TP53 | |
| SCHEMBL6622354 | 0.76 | MAPT (0.68) | KDM4EHTTMAPTHSD17B10TSHR | |
| SCHEMBL6621720 | 0.75 | MAPT (0.43) | KDM4EMAPTGAAKMT2APOLB | |
| SCHEMBL11780453 | 0.74 | KDM4E (0.61) | KDM4EHTTMAPTHSD17B10TP53 | |
| SCHEMBL23087551 | 0.74 | HTT (0.50) | KDM4EHTTMAPTHSD17B10TP53 | |
| SCHEMBL6621295 | 0.73 | HPGD (0.46) | KDM4EHTTMAPTHSD17B10TP53 | |
| SCHEMBL29371684 | 0.73 | KDM4E (0.53) | KDM4EHTTMAPTHSD17B10TP53 | |
| SCHEMBL9643280 | 0.73 | ABCB11 (0.64) | KDM4EHTTMAPTHSD17B10TP53 | |
| SCHEMBL23535302 | 0.73 | HTT (0.60) | KDM4EHTTMAPTHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474140-A1 | 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS | Pharmagene Laboratories Ltd (GB) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003068226-A1 | 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS | PHARMAGENE LABORATORIES LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |