Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12955391 | 0.74 | NPC1 (0.47) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL24696326 | 0.74 | TSHR (0.57) | POLBALDH1A1L3MBTL1 | |
| SCHEMBL14186001 | 0.74 | HPGD (0.47) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2123261 | 0.74 | ALDH1A1 (0.44) | SMN1; SMN2RAB9ANPC1MAPK1MEN1 | |
| SCHEMBL6609811 | 0.72 | ALDH1A1 (0.51) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2665746 | 0.72 | TSHR (0.73) | SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL18074482 | 0.71 | HTT (0.53) | SMN1; SMN2NPC1POLBALDH1A1HSD17B10 | |
| SCHEMBL11953188 | 0.71 | TSHR (0.45) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL14185996 | 0.71 | MAOB (0.47) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL6616501 | 0.71 | TSHR (0.45) | SMN1; SMN2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456182-A1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | AstraZeneca AB (SE) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003048133-A1 | PYRIMIDINE DERIVATIVES AS MODULATORS OF INSULINE-LIKE GROWTH FACTOR-1 RECEPTOR (IGF-I) | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |