Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.65 |
| ▸ | CDK4 | P11802 | 7/20 | 0.65 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6387033 | 0.83 | CDK2 (0.50) | CDK2CDK4SYKCCNA2CCNA1 | |
| SCHEMBL4021385 | 0.81 | CDK2 (0.48) | CDK2CDK4SYKCCNA2CCNA1 | |
| SCHEMBL6824629 | 0.79 | SYK (0.44) | CDK2CDK4SYKGSK3BCCNE1 | |
| SCHEMBL6621418 | 0.79 | CDK2 (0.56) | CDK2CDK4GSK3BCCNE1CCNT1 | |
| SCHEMBL6410279 | 0.79 | CDK2 (1.00) | CDK2CDK4GSK3BCCNE1CCNT1 | |
| SCHEMBL6603729 | 0.76 | CDK2 (0.51) | CDK2CDK4SYKCCNA2CCNA1 | |
| SCHEMBL6604728 | 0.74 | CDK2 (0.48) | CDK2CDK4SYKCCNA2CCNA1 | |
| SCHEMBL6443063 | 0.72 | CDK2 (0.58) | CDK2CDK4SYKCDK1IKBKB | |
| SCHEMBL6604316 | 0.71 | CDK2 (0.50) | CDK2CDK4SYKCCNA2CCNA1 | |
| SCHEMBL6605982 | 0.70 | CDK2 (0.49) | CDK2CDK4SYKCCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487823-A1 | DERIVATIVES OF 4-(IMIDAZOL-5-YL)-2-(4-SULFOANILINO)PYRIMIDINE WITH CDK INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2004-12-22 | — | — | EP | claimed |
| WO-2003076436-A1 | DERIVATIVES OF 4- (IMIDAZOL-5-YL)-2-(4-SULFOANILINO) PYRIMIDINE WITH CDK INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | claimed |