Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632665 | 0.88 | ADORA2A (0.63) | ADRA2AADRA2BADRA2CADORA2AADORA2B | |
| SCHEMBL6632330 | 0.88 | ADRA2A (0.71) | ADRA2AADRA2BADRA2CADORA2AADORA2B | |
| SCHEMBL6624412 | 0.88 | ADRA2A (0.62) | ADRA2AADRA2BADRA2CADORA2AADORA2B | |
| SCHEMBL6631565 | 0.87 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADORA2AADORA2B | |
| SCHEMBL6631798 | 0.87 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CADORA2AADORA1 | |
| SCHEMBL6635084 | 0.87 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CADORA2AADORA1 | |
| SCHEMBL6622066 | 0.87 | ADORA2A (0.61) | ADRA2AADRA2BADRA2CADORA2AADORA1 | |
| SCHEMBL6631701 | 0.86 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CADORA2AADORA2B | |
| SCHEMBL6632830 | 0.86 | ADRA2A (0.58) | ADRA2AADRA2BADRA2CADORA2AADORA1 | |
| SCHEMBL6633011 | 0.85 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976753-B1 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2004-01-02 | — | — | EP | disclosed |
| US-6222035-B1 | AS ADENOSINE A.SUB.2A RECEPTOR ANTAGONISTS AND ARE USEFUL FOR THERAPY OR OR PROPHYLAXIS OF VARIOUS DISEASES INDUCED BY HYPERACTIVITY OF ADENOSINE A.SUB.2A RECEPTORS SUCH AS PARKINSON'S DISEASE, SENILE DEMENTIA OR DEPRESSION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-24 | — | — | US | disclosed |