Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.77 |
| ▸ | SRC | P12931 | 10/20 | 0.77 |
| ▸ | BTK | Q06187 | 10/20 | 0.77 |
| ▸ | TEK | Q02763 | 9/20 | 0.77 |
| ▸ | KDR | P35968 | 4/20 | 0.77 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.66 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.66 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.62 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 5/20 | 0.58 |
| ▸ | ITK | Q08881 | 2/20 | 0.58 |
| ▸ | LYN | P07948 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | YES1 | P07947 | 1/20 | 0.57 |
| ▸ | HCK | P08631 | 1/20 | 0.57 |
| ▸ | FGR | P09769 | 1/20 | 0.57 |
| ▸ | FER | P16591 | 1/20 | 0.57 |
| ▸ | CSK | P41240 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623453 | 1.00 | LCK (0.77) | LCKSRCBTKTEKKDR | |
| Acetic Acid SCHEMBL6431633 | 0.98 | LCK (0.74) | LCKSRCBTKTEKKDR | |
| Acetic Acid SCHEMBL6431629 | 0.98 | LCK (0.74) | LCKSRCBTKTEKKDR | |
| Acetic Acid SCHEMBL6430316 | 0.94 | LCK (0.72) | LCKSRCBTKTEKKDR | |
| Acetic Acid SCHEMBL6430318 | 0.94 | LCK (0.72) | LCKSRCBTKTEKKDR | |
| Acetic Acid SCHEMBL6432590 | 0.92 | LCK (0.72) | LCKSRCBTKTEKKDR | |
| Acetic Acid SCHEMBL6432593 | 0.92 | LCK (0.72) | LCKSRCBTKTEKKDR | |
| Acetic Acid SCHEMBL6430767 | 0.91 | BTK (0.72) | LCKSRCBTKTEKKDR | |
| Acetic Acid SCHEMBL6430777 | 0.91 | BTK (0.72) | LCKSRCBTKTEKKDR | |
| SCHEMBL6431635 | 0.90 | LCK (0.68) | LCKSRCBTKTEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212327-B8 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2004-02-25 | — | — | EP | disclosed |
| EP-1212327-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019829-A2 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |