Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 4/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622074 | 0.92 | SCN9A (0.37) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6620167 | 0.91 | CCR3 (0.41) | MAPTACACBCCR3SCN9ATP53 | |
| SCHEMBL6620915 | 0.88 | CYP3A4 (0.43) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5762925 | 0.84 | MAPT (0.36) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5761023 | 0.83 | MAPT (0.38) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5762210 | 0.83 | MAPT (0.35) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5333712 | 0.81 | MAPT (0.36) | MAPTMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6620453 | 0.81 | SCN9A (0.35) | MAPTMEN1KMT2AACACBEPHX2 | |
| SCHEMBL6620293 | 0.80 | CNR1 (0.49) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6702187 | 0.78 | CCR3 (0.42) | CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487435-A1 | AZETIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS | Novartis AG (CH) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003077907-A1 | AZETIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2003-09-25 | — | — | WO | disclosed |