Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 15/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27545638 | 0.89 | PNMT (0.58) | SLC6A2SLC6A4SLC6A3PRMT5WDR77 | |
| SCHEMBL5188989 | 0.81 | PNMT (0.53) | SLC6A2SLC6A4SLC6A3PNMTDPP4 | |
| SCHEMBL8281716 | 0.81 | PNMT (0.53) | SLC6A2SLC6A4SLC6A3PNMTDPP4 | |
| SCHEMBL7989193 | 0.76 | DPP4 (0.49) | SLC6A2DPP4 | |
| SCHEMBL4509763 | 0.76 | PRMT5 (0.48) | SLC6A2SLC6A4SLC6A3PRMT5WDR77 | |
| SCHEMBL27478385 | 0.76 | DPP4 (0.51) | SLC6A2SLC6A4SLC6A3DPP4SIGMAR1 | |
| SCHEMBL4504290 | 0.75 | PRMT5 (0.47) | SLC6A2SLC6A4SLC6A3PRMT5WDR77 | |
| SCHEMBL5787568 | 0.73 | DPP4 (0.49) | SLC6A2SLC6A4SLC6A3DPP4 | |
| SCHEMBL29534946 | 0.72 | PRMT5 (0.65) | SLC6A2SLC6A4SLC6A3PRMT5WDR77 | |
| SCHEMBL1691782 | 0.72 | PRMT5 (0.65) | SLC6A2SLC6A4SLC6A3PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436269-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033482-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |