Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4008924 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9ACYP2C19SIGMAR1 | |
| SCHEMBL15114686 | 0.81 | DDB1 (0.50) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13993297 | 0.77 | DDB1 (0.46) | SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3558511 | 0.77 | ALDH1A1 (0.46) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL31693671 | 0.76 | CYP3A4 (0.57) | SMN1; SMN2CYP2C19SIGMAR1 | |
| SCHEMBL4458445 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AFKBP1ACYP2C19 | |
| SCHEMBL2467792 | 0.76 | MEN1 (0.58) | RAB9A | |
| SCHEMBL31693682 | 0.75 | CYP3A4 (0.58) | SMN1; SMN2CYP2C19SIGMAR1 | |
| SCHEMBL13993260 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL30968715 | 0.74 | ALDH1A1 (0.52) | SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268449-A4 | SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS | MERCK & CO INC (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-1268449-A1 | SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070708-A1 | SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2001-09-27 | — | — | WO | disclosed |