Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4679419 | 0.96 | HPGD (0.69) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL4682432 | 0.80 | HPGD (0.72) | HPGDLMNAALDH1A1SMN1; SMN2TRPA1 | |
| SCHEMBL10805990 | 0.79 | HPGD (0.65) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL12877951 | 0.79 | HPGD (0.70) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL4682438 | 0.79 | HPGD (0.70) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL4679490 | 0.79 | HPGD (1.00) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1242290 | 0.79 | HPGD (0.70) | HPGDLMNAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL4682930 | 0.78 | LMNA (0.64) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6560658 | 0.78 | LMNA (0.50) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL10811292 | 0.77 | CYP3A4 (0.59) | HPGDLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |