Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | AGXT | P21549 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3257946 | 0.86 | DHFR (0.60) | DHFRHSD11B1IDO1AGXT | |
| SCHEMBL7234370 | 0.86 | DHFR (0.57) | DHFRALDH1A1HSD11B1KDM4CNPC1 | |
| SCHEMBL7772717 | 0.86 | DHFR (0.57) | DHFRALDH1A1HSD11B1KDM4CNPC1 | |
| SCHEMBL31052241 | 0.83 | DHFR (0.60) | DHFRALDH1A1HSD11B1KDM4C | |
| SCHEMBL29646513 | 0.83 | DHFR (0.57) | DHFRALDH1A1HSD11B1KDM4CLMNA | |
| SCHEMBL25219553 | 0.83 | DHFR (0.60) | DHFRALDH1A1HSD11B1KDM4C | |
| SCHEMBL10182225 | 0.83 | DHFR (0.57) | DHFRALDH1A1HSD11B1KDM4CNPC1 | |
| SCHEMBL2464134 | 0.83 | DHFR (0.57) | DHFRALDH1A1HSD11B1KDM4CNPC1 | |
| SCHEMBL21257491 | 0.83 | DHFR (0.57) | DHFRALDH1A1HSD11B1KDM4CNPC1 | |
| SCHEMBL13140896 | 0.83 | DHFR (0.57) | DHFRALDH1A1HSD11B1KDM4CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485091-A1 | THIAZOLE AND OXAZOLE DERIVATIVES THAT MODULATE PPAR ACTIVITY | Warner-Lambert Company LLC (US) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003074052-A1 | THIAZOLE AND OXAZOLE DERIVATIVES THAT MODULATE PPAR ACTIVITY | WARNER-LAMBERT COMPANY LLC (US) | 2003-09-12 | — | — | WO | disclosed |