Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624262 | 1.00 | HTT (0.41) | HTTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6623465 | 0.81 | TAAR1 (0.42) | HTTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6623467 | 0.81 | TAAR1 (0.42) | HTTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6625783 | 0.81 | GAA (0.48) | HTTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6625786 | 0.81 | GAA (0.48) | HTTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL30371825 | 0.79 | TAAR1 (0.47) | HTTSMN1; SMN2LMNATAAR1BACE1 | |
| SCHEMBL6624952 | 0.79 | TAAR1 (0.47) | HTTSMN1; SMN2LMNATAAR1BACE1 | |
| SCHEMBL6624949 | 0.79 | TAAR1 (0.47) | HTTSMN1; SMN2LMNATAAR1BACE1 | |
| SCHEMBL2116652 | 0.74 | AKR1B1 (0.42) | HTTNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2116651 | 0.74 | AKR1B1 (0.42) | HTTNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1035114-B1 | Processes for the preparation of nitrogen-heterocyclic compounds | TOSOH CORP (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-6346621-B1 | INDOLE OR QUINOLINE COMPOUNDS SUBSTITUTED WITH AMINO COMPOUNDS ON NITROGEN | TOSOH CORPORATION (JP) | 2002-02-12 | — | — | US | disclosed |
| EP-1035114-A2 | Nitrogen-heterocyclic compounds and process for production thereof | TOSOH CORPORATION (JP) | 2000-09-13 | — | — | EP | disclosed |