Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.69 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.69 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.69 |
| ▸ | PDE2A | O00408 | 1/20 | 0.69 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.69 |
| ▸ | PDE6D | O43924 | 1/20 | 0.69 |
| ▸ | PDE8A | O60658 | 1/20 | 0.69 |
| ▸ | PDE9A | O76083 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | PDE6A | P16499 | 1/20 | 0.69 |
| ▸ | PDE6G | P18545 | 1/20 | 0.69 |
| ▸ | PDE4A | P27815 | 1/20 | 0.69 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | PDE6B | P35913 | 1/20 | 0.69 |
| ▸ | PDE6C | P51160 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399340 | 0.93 | PDE5A (0.70) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL7360646 | 0.92 | PDE5A (0.59) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL7402702 | 0.91 | PDE5A (0.71) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL6622526 | 0.87 | PDE5A (0.59) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL6621801 | 0.86 | PDE5A (0.62) | PDE5APDE3BPDE3AABCC4PDE2A | |
| SCHEMBL5604461 | 0.83 | PDE5A (0.75) | PDE5APDE3BPDE3AABCC4PDE2A | |
| Sildenafil SCHEMBL5683880 | 0.82 | PDE5A (1.00) | PDE5APDE3BPDE3AABCC4PDE2A | |
| Sildenafil SCHEMBL29361663 | 0.82 | PDE5A (1.00) | PDE5APDE3BPDE3AABCC4PDE2A | |
| Sildenafil SCHEMBL1895 | 0.82 | PDE5A (1.00) | PDE5APDE3BPDE3AABCC4PDE2A | |
| Sildenafil SCHEMBL7915871 | 0.81 | PDE5A (0.98) | PDE5APDE3BPDE3AABCC4PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109814-B1 | 5-HETEROCYCLYL PYRAZOLO 4,3-D]PYRIMIDIN-7-ONES FOR THE TREATMENT OF MALE ERECTILE DYSFUNCTION | ORTHO MCNEIL PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2001003644-A9 | PYRAZOLOPYRIMIDINONE DERIVATIVES CONJUGATED TO THIOPHENE MOIETIES OR BENZO [FUSED] 5-MEMBERED HETEROCYCLES FOR ERECTILE DYSFUNCTION | PICOWER INST MED RES (US) | 2001-11-29 | — | — | WO | disclosed |
| WO-2001003644-A2 | PYRAZOLOPYRIMIDINONE DERIVATIVES CONJUGATED TO THIOPHENE MOIETIES OR BENZO [FUSED] 5-MEMBERED HETEROCYCLES FOR ERECTILE DYSFUNCTION | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 2001-01-18 | — | — | WO | disclosed |
| US-6077841-A | FOR TREATING SEXUAL DISORDERS, MALE IMPOTENCY, HEART FAILURE, PULMONARY HYPERTENSION, AND ANGINA | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-06-20 | — | — | US | disclosed |