Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | PDE1A | P54750 | 3/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | PDE6C | P51160 | 3/20 | 0.57 |
| ▸ | PDE2A | O00408 | 2/20 | 0.57 |
| ▸ | PDE9A | O76083 | 2/20 | 0.57 |
| ▸ | PDE4A | P27815 | 2/20 | 0.57 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.57 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.57 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.57 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.57 |
| ▸ | PDE6D | O43924 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624319 | 0.86 | PDE5A (0.69) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL6619696 | 0.86 | PDE5A (0.57) | PDE5AKMT2AKDM4EPDE1APDE1B | |
| SCHEMBL7399340 | 0.86 | PDE5A (0.70) | PDE5AKMT2AKDM4EPDE1APDE1B | |
| SCHEMBL7360646 | 0.84 | PDE5A (0.59) | PDE5AKMT2APDE1APDE1BPDE1C | |
| SCHEMBL7402702 | 0.83 | PDE5A (0.71) | PDE5APDE1APDE1BPDE1CPDE6C | |
| SCHEMBL1071 | 0.82 | KMT2A (0.83) | PDE5AKMT2AKDM4EPDE1APDE1B | |
| SCHEMBL29655374 | 0.82 | KMT2A (0.83) | PDE5AKMT2AKDM4EPDE1APDE1B | |
| SCHEMBL7428886 | 0.79 | PDE5A (0.68) | PDE5AKMT2AKDM4EPDE1APDE1B | |
| SCHEMBL6628860 | 0.77 | KMT2A (0.85) | PDE5AKMT2AKDM4EPDE1APDE1B | |
| SCHEMBL21067487 | 0.76 | PDE5A (1.00) | PDE5AKMT2AKDM4EPDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109814-B1 | 5-HETEROCYCLYL PYRAZOLO 4,3-D]PYRIMIDIN-7-ONES FOR THE TREATMENT OF MALE ERECTILE DYSFUNCTION | ORTHO MCNEIL PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| US-6077841-A | FOR TREATING SEXUAL DISORDERS, MALE IMPOTENCY, HEART FAILURE, PULMONARY HYPERTENSION, AND ANGINA | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-06-20 | — | — | US | disclosed |