Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | FYN | P06241 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | GAB1 | Q13480 | 2/20 | 0.38 |
| ▸ | IRS1 | P35568 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3251304 | 0.90 | HSD11B1 (0.49) | HSD11B1POLBMEN1KMT2ANPC1 | |
| SCHEMBL3252292 | 0.88 | HSD11B1 (0.51) | HSD11B1MEN1KMT2A | |
| SCHEMBL3248063 | 0.82 | HPGD (0.51) | HSD11B1POLBMEN1KMT2AHPGD | |
| SCHEMBL3256147 | 0.81 | TSHR (0.53) | HSD11B1POLBKMT2AHPGDAKT1 | |
| SCHEMBL3250348 | 0.80 | HSD11B1 (0.52) | HSD11B1PTGS2POLBMEN1KMT2A | |
| SCHEMBL3253323 | 0.80 | HSD11B1 (0.50) | HSD11B1POLBMEN1KMT2AHPGD | |
| SCHEMBL3253320 | 0.80 | HSD11B1 (0.50) | HSD11B1POLBMEN1KMT2AHPGD | |
| SCHEMBL3254312 | 0.80 | MAPT (0.52) | HSD11B1PTGS2POLBMEN1KMT2A | |
| SCHEMBL5964659 | 0.78 | AKT1 (0.45) | MEN1KMT2AAKT1GAB1IRS1 | |
| SCHEMBL3256711 | 0.76 | AKT1 (0.56) | AKT1GAB1IRS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003043999-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | disclosed |