Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 7/20 | 0.42 |
| ▸ | IL1B | P01584 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 10/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6674264 | 0.92 | CASP1 (0.39) | CASP1IL1BLCKHCRTR1HCRTR2 | |
| SCHEMBL6627409 | 0.92 | CASP1 (0.42) | CASP1IL1BLCKHCRTR1HCRTR2 | |
| SCHEMBL6628797 | 0.92 | CASP1 (0.42) | CASP1IL1BLCKHCRTR1HCRTR2 | |
| SCHEMBL6627596 | 0.90 | CASP1 (0.41) | CASP1IL1BLCKHCRTR1HCRTR2 | |
| SCHEMBL6627592 | 0.90 | CASP1 (0.41) | CASP1IL1BLCKHCRTR1HCRTR2 | |
| SCHEMBL6627853 | 0.89 | CASP1 (0.39) | CASP1IL1BLCKHCRTR1HCRTR2 | |
| SCHEMBL7088546 | 0.87 | HCRTR1 (0.41) | CASP1IL1BLCKHCRTR1HCRTR2 | |
| SCHEMBL6627535 | 0.83 | CASP1 (0.42) | CASP1IL1BLCKMMEACE | |
| SCHEMBL6626401 | 0.83 | CASP1 (0.48) | CASP1IL1BLCK | |
| SCHEMBL6628142 | 0.83 | CASP1 (0.48) | CASP1IL1BLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248787-B1 | NOVEL SUBTITUTED PYRAZOLO[4,3-e]DIAZEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE AS MEDICINAL PRODUCTS AND PROCESSES FOR PREPARING THEM | WARNER LAMBERT CO (US) | 2004-10-06 | — | — | EP | claimed |
| EP-1246824-B1 | CARBOXAMIDE DIAZEPIN DERIVATIVES, PREPARATION METHOD, USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2004-06-09 | — | — | EP | claimed |
| EP-1246824-B1 | CARBOXAMIDE DIAZEPIN DERIVATIVES, PREPARATION METHOD, USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2004-06-09 | — | — | EP | disclosed |