Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.46 |
| ▸ | MMP13 | P45452 | 15/20 | 0.46 |
| ▸ | MMP1 | P03956 | 10/20 | 0.46 |
| ▸ | MMP9 | P14780 | 4/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033016 | 0.81 | ADAM17 (0.58) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL4024000 | 0.80 | ADAM17 (0.60) | ADAM17MMP13MMP1MMP9 | |
| SCHEMBL4023877 | 0.78 | ADAM17 (0.62) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL4030079 | 0.76 | ADAM17 (0.66) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL4027905 | 0.73 | ADAM17 (0.81) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL7249318 | 0.71 | ADAM17 (0.63) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL4029281 | 0.70 | ADAM17 (0.74) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL3941410 | 0.69 | ADAM17 (0.71) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL3942770 | 0.69 | ADAM17 (0.63) | ADAM17MMP13MMP1MMP9MMP2 | |
| SCHEMBL3938817 | 0.68 | ADAM17 (0.72) | ADAM17MMP13MMP1MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144368-B1 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | WYETH CORP (US) | 2004-07-14 | — | — | EP | disclosed |