Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594278 | 0.90 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11CA1CA2 | |
| SCHEMBL6593174 | 0.88 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11CA1CA2 | |
| SCHEMBL6589529 | 0.86 | ABCC9 (0.49) | ABCC9ABCC8KCNJ11CA1CA2 | |
| SCHEMBL6592710 | 0.85 | CA1 (0.44) | ABCC9ABCC8KCNJ11CA1CA2 | |
| SCHEMBL6592791 | 0.85 | ABCC9 (0.37) | ABCC9ABCC8KCNJ11LMNAALDH1A1 | |
| SCHEMBL6591147 | 0.82 | CA1 (0.54) | CA1CA2CA12CA7CA14 | |
| SCHEMBL4254830 | 0.81 | ABCC9 (0.50) | ABCC9ABCC8KCNJ11CA1CA2 | |
| SCHEMBL6591449 | 0.81 | ABCC9 (0.42) | ABCC9ABCC8KCNJ11CA1CA2 | |
| SCHEMBL6594026 | 0.79 | HCRTR1 (0.34) | ABCC9ABCC8KCNJ11LMNAALDH1A1 | |
| SCHEMBL4267588 | 0.79 | MAPT (0.48) | ABCC9ABCC8KCNJ11CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842927-B1 | 3-Amido-chromanylsulfonyl(thio)ureas, process for their preparation, their use and medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-02-25 | — | — | EP | disclosed |
| US-5849755-A | 3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| EP-0842927-A1 | 3-Amido-chromanylsulfonyl(thio)ureas, process for their preparation, their use and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-20 | — | — | EP | disclosed |