Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 0.69 |
| ▸ | MMP9 | P14780 | 12/20 | 0.69 |
| ▸ | MMP1 | P03956 | 9/20 | 0.69 |
| ▸ | ADAM17 | P78536 | 12/20 | 0.59 |
| ▸ | MMP3 | P08254 | 3/20 | 0.52 |
| ▸ | MMP7 | P09237 | 2/20 | 0.52 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | MMP13 | P45452 | 2/20 | 0.52 |
| ▸ | MMP14 | P50281 | 2/20 | 0.52 |
| ▸ | MMP15 | P51511 | 1/20 | 0.52 |
| ▸ | MMP16 | P51512 | 1/20 | 0.52 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.52 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628527 | 0.93 | MMP2 (0.75) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL6630955 | 0.91 | MMP2 (0.78) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL6626865 | 0.89 | MMP2 (0.76) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL6631455 | 0.86 | MMP2 (0.67) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL27520345 | 0.86 | MMP2 (0.67) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL6630353 | 0.84 | MMP2 (0.71) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL13274077 | 0.82 | MMP2 (1.00) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL6838778 | 0.82 | MMP2 (1.00) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL6628081 | 0.82 | MMP2 (0.52) | MMP2MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7353396 | 0.81 | MMP2 (0.72) | MMP2MMP9MMP1ADAM17MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027332-B1 | NOVEL LACTAM METALLOPROTEASE INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-05-26 | — | — | EP | claimed |
| EP-1385847-A2 | PYRAZOLO[1,5-A]PYRIDINE DERIVATIVES | SmithKline Beecham Corporation (US) | 2004-02-04 | — | — | EP | disclosed |
| US-6610731-B2 | Antiinflammatory | BRISTOL-MYERS SQUIBB COMPANY | 2003-08-26 | — | — | US | disclosed |
| WO-2002088124-A2 | PYRAZOLO'1,5-A!PYRIDINE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-11-07 | — | — | WO | disclosed |