Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29085286 | 0.91 | CYP19A1 (0.61) | CYP19A1ABCG2ABCB1POLBMEN1 | |
| SCHEMBL661408 | 0.91 | CYP19A1 (0.59) | CYP19A1ABCG2ABCB1POLBMEN1 | |
| SCHEMBL664361 | 0.88 | CYP19A1 (0.67) | CYP19A1ABCG2ABCB1POLBMEN1 | |
| SCHEMBL3543073 | 0.88 | CYP19A1 (0.58) | CYP19A1ABCG2ABCB1POLBMEN1 | |
| SCHEMBL30536901 | 0.87 | CYP19A1 (0.64) | CYP19A1ABCG2ABCB1POLBMEN1 | |
| SCHEMBL29085238 | 0.83 | CYP19A1 (0.67) | CYP19A1ABCG2ABCB1POLBMEN1 | |
| SCHEMBL29204369 | 0.83 | NPC1 (0.67) | CYP19A1ABCG2ABCB1POLBMEN1 | |
| Demethoxymatteucinol SCHEMBL664144 | 0.79 | ABCG2 (0.64) | CYP19A1ABCG2ABCB1POLBMEN1 | |
| Demethoxymatteucinol SCHEMBL29204370 | 0.79 | ABCG2 (0.64) | CYP19A1ABCG2ABCB1POLBMEN1 | |
| SCHEMBL9063227 | 0.76 | CYP19A1 (0.70) | CYP19A1ABCG2ABCB1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046353-A1 | CLEISTOCALYX OPERCULATUS-DERIVED COMPOUNDS HAVING INHIBITORY ACTIVITIES AGAINST AVIAN AND SWINE INFLUENZA VIRUSES OR NOVEL INFLUENZA VIRUS | CHOONG ANG VACCINE LAB. (KR) | 2012-02-23 | — | — | US | claimed |
| WO-2012023660-A1 | ANTIVIRAL DRUG FOR AVIAN AND SWINE INFLUENZA AND NOVEL FLU, OBTAINED FROM CLEISTOCALYX OPERCULATUS | 주식회사 중앙백신연구소 (KR) | 2012-02-23 | — | — | WO | claimed |
| US-20120046353-A1 | CLEISTOCALYX OPERCULATUS-DERIVED COMPOUNDS HAVING INHIBITORY ACTIVITIES AGAINST AVIAN AND SWINE INFLUENZA VIRUSES OR NOVEL INFLUENZA VIRUS | CHOONG ANG VACCINE LAB. (KR) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046353-A1 | CLEISTOCALYX OPERCULATUS-DERIVED COMPOUNDS HAVING INHIBITORY ACTIVITIES AGAINST AVIAN AND SWINE INFLUENZA VIRUSES OR NOVEL INFLUENZA VIRUS | PIGS, CLEC4M, ENGASE | CYP19A1 4094/4885ABCG2 1926/4885ABCB1 4746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.