Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500741 | 1.00 | POLB (0.57) | POLBKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL12569137 | 0.82 | TSHR (0.68) | POLBKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL5104062 | 0.78 | POLB (0.63) | POLBKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL9003051 | 0.76 | KMT2A (0.68) | POLBKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL9003054 | 0.76 | KMT2A (0.68) | POLBKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL6487784 | 0.75 | S1PR1 (0.37) | POLBKMT2ALMNAALDH1A1 | |
| SCHEMBL5104059 | 0.74 | POLB (0.62) | POLBKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL19617048 | 0.74 | LMNA (0.76) | POLBKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL1343383 | 0.71 | KMT2A (0.61) | POLBKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL3119295 | 0.69 | TSHR (0.69) | POLBKMT2ALMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187828-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2004-04-21 | — | — | EP | disclosed |
| EP-1187828-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000078748-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-12-28 | — | — | WO | disclosed |