Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | IRS1 | P35568 | 2/20 | 0.35 |
| ▸ | GAB1 | Q13480 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3256154 | 0.83 | HSD11B1 (0.55) | HSD11B1HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL3248063 | 0.81 | HPGD (0.51) | HSD11B1HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL3256635 | 0.78 | AKT1 (0.51) | HPGDALDH1A1KMT2AMEN1AKT1 | |
| SCHEMBL3250317 | 0.76 | HSD11B1 (0.66) | HSD11B1HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL3254353 | 0.76 | HSD11B1 (0.60) | HSD11B1ALDH1A1KMT2AGAATSHR | |
| SCHEMBL3255541 | 0.76 | HSD11B1 (0.54) | HSD11B1KMT2AMAPT | |
| SCHEMBL3258736 | 0.75 | ABCB1 (0.39) | HSD11B1HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL3256147 | 0.74 | TSHR (0.53) | HSD11B1HPGDALDH1A1KMT2AAKT1 | |
| SCHEMBL3251304 | 0.74 | HSD11B1 (0.49) | HSD11B1HPGDALDH1A1KMT2AMEN1 | |
| SCHEMBL3253323 | 0.73 | HSD11B1 (0.50) | HSD11B1HPGDALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003043999-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-05-30 | — | — | WO | disclosed |