Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 18/20 | 0.74 |
| ▸ | ADORA1 | P30542 | 17/20 | 0.74 |
| ▸ | ADORA2A | P29274 | 16/20 | 0.74 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625122 | 0.89 | ADORA3 (0.71) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL6624738 | 0.88 | ADORA3 (0.77) | ADORA3ADORA1ADORA2AADORA2BCYP1A2 | |
| SCHEMBL6628140 | 0.85 | ADORA3 (0.75) | ADORA3ADORA1ADORA2AADORA2BHSD17B10 | |
| SCHEMBL6624990 | 0.85 | ADORA3 (0.72) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL6625572 | 0.85 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL6624221 | 0.84 | ADORA3 (0.74) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL6626213 | 0.82 | ADORA3 (0.78) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL6623345 | 0.82 | ADORA3 (0.78) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL6623973 | 0.82 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL6625034 | 0.78 | ADORA3 (0.71) | ADORA3ADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976753-B1 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2004-01-02 | — | — | EP | disclosed |
| US-6222035-B1 | AS ADENOSINE A.SUB.2A RECEPTOR ANTAGONISTS AND ARE USEFUL FOR THERAPY OR OR PROPHYLAXIS OF VARIOUS DISEASES INDUCED BY HYPERACTIVITY OF ADENOSINE A.SUB.2A RECEPTORS SUCH AS PARKINSON'S DISEASE, SENILE DEMENTIA OR DEPRESSION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-24 | — | — | US | disclosed |
| EP-0976753-A1 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-02 | — | — | EP | disclosed |