Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | CPA1 | P15085 | 1/20 | 0.32 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21708634 | 0.83 | TET2 (0.39) | ALDH1A1LMNAMAPTTSHRCYP2C19 | |
| SCHEMBL1852852 | 0.80 | EGLN1 (0.40) | EGLN1ALDH1A1LMNAMAPTPTGS2 | |
| SCHEMBL164110 | 0.77 | — | — | |
| SCHEMBL11659340 | 0.76 | GAA (0.45) | ALDH1A1LMNAMAPTTSHR | |
| SCHEMBL7077043 | 0.75 | — | — | |
| SCHEMBL287612 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL5886752 | 0.75 | CYP2D6 (0.48) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL287613 | 0.75 | — | — | |
| SCHEMBL31198187 | 0.75 | CYP2D6 (0.48) | ALDH1A1LMNAMAPTPTGS2TDP1 | |
| SCHEMBL7219713 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0960108-B1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2004-10-27 | — | — | EP | disclosed |
| US-6194451-B1 | PREVENT RELEASE TUMOR NECROSIS FACTOR; ANTIINFLAMMATORY AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-02-27 | — | — | US | disclosed |
| EP-0960108-A1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998033788-A1 | MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-08-06 | — | — | WO | disclosed |