Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.69 |
| ▸ | HTR2B | P41595 | 12/20 | 0.69 |
| ▸ | HTR2A | P28223 | 12/20 | 0.69 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630061 | 0.85 | HTR2C (0.66) | HTR2CHTR2BHTR2ADRD2DRD3 | |
| SCHEMBL6628642 | 0.83 | HTR2C (0.68) | HTR2CHTR2BHTR2ADRD2DRD3 | |
| SCHEMBL6408224 | 0.82 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL6628271 | 0.80 | HTR2C (0.69) | HTR2CHTR2BHTR2ADRD2DRD3 | |
| SCHEMBL6629920 | 0.79 | HTR2C (0.70) | HTR2CHTR2BHTR2ADRD2DRD3 | |
| SCHEMBL6412082 | 0.79 | HTR2C (1.00) | HTR2CHTR2BHTR2A | |
| SCHEMBL6412104 | 0.76 | HTR2C (0.67) | HTR2CHTR2BHTR2A | |
| SCHEMBL11467627 | 0.76 | CHRNB4 (0.48) | HTR2CHTR2ADRD2DRD3 | |
| SCHEMBL6414633 | 0.73 | HTR2C (0.62) | HTR2CHTR2BHTR2A | |
| SCHEMBL11457031 | 0.73 | CHRNB4 (0.52) | HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465630-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2004-10-13 | — | — | EP | claimed |
| WO-2003057220-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2003-07-17 | — | — | WO | claimed |
| EP-1465630-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057220-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2003-07-17 | — | — | WO | disclosed |