Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.69 |
| ▸ | HTR2A | P28223 | 12/20 | 0.69 |
| ▸ | HTR2B | P41595 | 13/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629920 | 0.93 | HTR2C (0.70) | HTR2CHTR2AHTR2BHTR1ACYP2D6 | |
| SCHEMBL6630061 | 0.89 | HTR2C (0.66) | HTR2CHTR2AHTR2BHTR1ACYP2D6 | |
| SCHEMBL6628642 | 0.84 | HTR2C (0.68) | HTR2CHTR2AHTR2BHTR1ACYP2D6 | |
| SCHEMBL6413768 | 0.82 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRA1BDRD3 | |
| SCHEMBL6628017 | 0.80 | HTR2C (0.69) | HTR2CHTR2AHTR2BDRD2DRD3 | |
| SCHEMBL6407757 | 0.77 | HTR2C (0.69) | HTR2CHTR2AHTR2B | |
| SCHEMBL6629306 | 0.77 | HTR2C (0.50) | HTR2CHTR2AHTR2BHTR1ACYP2D6 | |
| SCHEMBL6410940 | 0.75 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRA1BDRD3 | |
| SCHEMBL11449105 | 0.74 | CHRNB4 (0.68) | — | |
| SCHEMBL6629013 | 0.73 | HTR2C (0.66) | HTR2CHTR2AHTR2BHTR1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465630-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003057220-A1 | CYCLIC UREA DERIVATIVES WITH 5-HT2C RECEPTOR ACTIVITY | GLAXO GROUP LIMITED (GB) | 2003-07-17 | — | — | WO | disclosed |