Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629853 | 0.90 | HTT (0.50) | MEN1KMT2AHTTALDH1A1MAOB | |
| SCHEMBL2872354 | 0.78 | NR1H2 (0.49) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL3174768 | 0.75 | MAPT (0.62) | LMNAMEN1KMT2AALDH1A1POLB | |
| SCHEMBL6482032 | 0.74 | KDM4E (0.51) | LMNAALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL6627174 | 0.72 | HPGD (0.49) | MEN1KMT2AHTTALDH1A1POLB | |
| SCHEMBL2868702 | 0.72 | NR1H2 (0.56) | KMT2AHTTALDH1A1POLBTDP1 | |
| SCHEMBL6627560 | 0.71 | KMT2A (0.45) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL7451163 | 0.71 | PDE10A (0.44) | LMNAMEN1KMT2AHTTGAA | |
| SCHEMBL6628176 | 0.71 | KMT2A (0.35) | LMNAMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL27814931 | 0.71 | NR1H2 (0.44) | HTTALDH1A1TP53SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004525942-A | — | — | 2004-08-26 | — | — | JP | claimed |
| US-20040116495-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-06-17 | — | — | US | claimed |
| EP-1379241-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002078699-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |
| US-20040116495-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2004-06-17 | — | — | US | disclosed |
| EP-1379241-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002078699-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |