Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687635 | 1.00 | CTSK (0.46) | CTSKCTSSCTSLPTPN2PTPN1 | |
| SCHEMBL6628528 | 0.82 | CTSK (0.37) | CTSKCTSSCTSLPTPN2PTPN1 | |
| SCHEMBL6061710 | 0.81 | MAPT (0.42) | CTSKPTPN2PTPN1 | |
| SCHEMBL6628447 | 0.81 | MAPT (0.42) | CTSKPTPN2PTPN1 | |
| SCHEMBL6630253 | 0.80 | ACACB (0.36) | CTSKCTSSPTPN2PTPN1 | |
| SCHEMBL6062971 | 0.80 | CTSK (0.51) | CTSKCTSSCTSL | |
| SCHEMBL6062962 | 0.80 | CTSK (0.51) | CTSKCTSSCTSL | |
| SCHEMBL6062966 | 0.80 | CTSK (0.51) | CTSKCTSSCTSL | |
| SCHEMBL6628525 | 0.78 | CTSK (0.55) | CTSKCTSSPTPN1 | |
| SCHEMBL9438805 | 0.76 | CTSK (0.60) | CTSKCTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | claimed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | claimed |
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | disclosed |