Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K9 | P80192 | 6/20 | 0.72 |
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.72 |
| ▸ | MAP3K10 | Q02779 | 3/20 | 0.72 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.72 |
| ▸ | KDR | P35968 | 2/20 | 0.72 |
| ▸ | PRKCA | P17252 | 5/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.60 |
| ▸ | PRKCG | P05129 | 3/20 | 0.60 |
| ▸ | PRKCB | P05771 | 3/20 | 0.60 |
| ▸ | PRKCH | P24723 | 3/20 | 0.60 |
| ▸ | PRKCI | P41743 | 3/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.60 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.60 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.60 |
| ▸ | CDK4 | P11802 | 2/20 | 0.55 |
| ▸ | CCND1 | P24385 | 2/20 | 0.55 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.55 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628462 | 0.85 | MAP3K9 (0.76) | MAP3K9MAP3K11MAP3K10NTRK1KDR | |
| SCHEMBL6630147 | 0.85 | MAP3K9 (0.76) | MAP3K9MAP3K11MAP3K10NTRK1KDR | |
| SCHEMBL6629555 | 0.85 | MAP3K9 (0.76) | MAP3K9MAP3K11MAP3K10NTRK1KDR | |
| SCHEMBL3082217 | 0.84 | MAP3K9 (1.00) | MAP3K9MAP3K11MAP3K10NTRK1KDR | |
| SCHEMBL6629697 | 0.84 | MAP3K9 (0.74) | MAP3K9MAP3K11MAP3K10NTRK1KDR | |
| SCHEMBL6632517 | 0.82 | MAP3K9 (0.72) | MAP3K9MAP3K11MAP3K10NTRK1KDR | |
| SCHEMBL6627011 | 0.81 | MAP3K9 (0.70) | MAP3K9MAP3K11MAP3K10NTRK1KDR | |
| SCHEMBL6627014 | 0.81 | MAP3K9 (0.70) | MAP3K9MAP3K11MAP3K10NTRK1KDR | |
| SCHEMBL9263506 | 0.81 | ROCK2 (0.78) | MAP3K9MAP3K11PRKCAPRKCQPRKCD | |
| SCHEMBL9260091 | 0.81 | ROCK2 (0.78) | MAP3K9MAP3K11PRKCAPRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1088823-B1 | Fused pyrrolocarbazoles | CEPHALON INC (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-0785938-B1 | FUSED PYRROLOCARBAZOLES | CEPHALON INC (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1088823-A1 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2001-04-04 | — | — | EP | disclosed |
| US-5705511-A | ENZYME INHIBITORS, ANTIINFLAMMATORY, TROPHIC FACTOR, ANTICANCER CELL GROWTH | CEPHALON, INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5591855-A | KINASE INHIBITORS, TROPHIC FACTOR-INDUCED ACTIVITY ENHANCEMENT, CELL SURVIVAL | CEPHALON, INC. (US) | 1997-01-07 | — | — | US | disclosed |