Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658522 | 0.83 | MAPT (0.53) | MAPTLMNAMEN1KMT2AXBP1 | |
| SCHEMBL6625696 | 0.80 | MAPT (0.49) | MAPTLMNAMEN1KMT2AXBP1 | |
| SCHEMBL6625454 | 0.74 | MAPK14 (0.34) | MAPTLMNAMEN1KMT2AXBP1 | |
| SCHEMBL6623328 | 0.72 | MAPK14 (0.32) | MAPTLMNAMEN1KMT2AXBP1 | |
| SCHEMBL5660474 | 0.71 | PDE4A (0.35) | LMNAALDH1A1SMN1; SMN2USP2HSD17B10 | |
| SCHEMBL6625714 | 0.71 | NR3C2 (0.33) | MAPTLMNAMEN1KMT2AXBP1 | |
| SCHEMBL5656848 | 0.70 | POLB (0.55) | MAPTLMNAMEN1KMT2AXBP1 | |
| SCHEMBL6625061 | 0.70 | POLB (0.40) | MAPTLMNAMEN1KMT2AXBP1 | |
| SCHEMBL6623042 | 0.67 | POLB (0.39) | MAPTLMNAKMT2AALDH1A1POLB | |
| SCHEMBL5656464 | 0.66 | MAPT (0.59) | MAPTLMNAMEN1KMT2AXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487792-A1 | DIHYDROINDOL-2-ONE DERIVATIVES AS STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078394-A1 | DIHYDROINDOL-2-ONE DERIVATIVES AS STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-09-25 | — | — | WO | disclosed |