Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658522 | 0.77 | MAPT (0.53) | MEN1LMNAMAPTXBP1KMT2A | |
| SCHEMBL6628587 | 0.72 | MAPT (0.37) | MAPK14MEN1LMNAMAPTXBP1 | |
| SCHEMBL6625454 | 0.72 | MAPK14 (0.34) | MAPK14MEN1LMNAMAPTXBP1 | |
| SCHEMBL6625603 | 0.72 | PDPK1 (0.40) | MAPK14MEN1LMNAMAPTXBP1 | |
| SCHEMBL6625714 | 0.71 | NR3C2 (0.33) | MEN1LMNAMAPTXBP1KMT2A | |
| SCHEMBL5660790 | 0.70 | SCN9A (0.30) | — | |
| SCHEMBL6623042 | 0.67 | POLB (0.39) | MAPK14LMNAMAPTKMT2A | |
| SCHEMBL5656848 | 0.64 | POLB (0.55) | MEN1LMNAMAPTXBP1KMT2A | |
| SCHEMBL6625692 | 0.64 | OTUD7B (0.40) | — | |
| SCHEMBL16322095 | 0.63 | MAPK14 (0.48) | MAPK14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487792-A1 | DIHYDROINDOL-2-ONE DERIVATIVES AS STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078394-A1 | DIHYDROINDOL-2-ONE DERIVATIVES AS STEROID HORMONE NUCLEAR RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-09-25 | — | — | WO | disclosed |