Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.71 |
| ▸ | MMP13 | P45452 | 18/20 | 0.71 |
| ▸ | MMP9 | P14780 | 17/20 | 0.71 |
| ▸ | MMP1 | P03956 | 16/20 | 0.71 |
| ▸ | MMP7 | P09237 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939487 | 0.88 | ADAM17 (0.78) | ADAM17MMP13MMP9MMP1MMP7 | |
| SCHEMBL4098466 | 0.87 | ADAM17 (0.71) | ADAM17MMP13MMP9MMP1MMP7 | |
| SCHEMBL6627777 | 0.86 | ADAM17 (0.70) | ADAM17MMP13MMP9MMP1MMP7 | |
| SCHEMBL3948365 | 0.86 | ADAM17 (0.81) | ADAM17MMP13MMP9MMP1MMP7 | |
| SCHEMBL3940480 | 0.85 | ADAM17 (0.69) | ADAM17MMP13MMP9MMP1MMP7 | |
| SCHEMBL4149331 | 0.85 | ADAM17 (0.80) | ADAM17MMP13MMP9MMP1MMP7 | |
| SCHEMBL3940997 | 0.84 | ADAM17 (0.82) | ADAM17MMP13MMP9MMP1MMP7 | |
| SCHEMBL3942404 | 0.84 | ADAM17 (0.81) | ADAM17MMP13MMP9MMP1MMP7 | |
| SCHEMBL3938305 | 0.84 | ADAM17 (0.77) | ADAM17MMP13MMP9MMP1MMP7 | |
| SCHEMBL3940092 | 0.84 | ADAM17 (0.83) | ADAM17MMP13MMP9MMP1MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144368-B1 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | WYETH CORP (US) | 2004-07-14 | — | — | EP | claimed |