Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.44 |
| ▸ | NPY4R | P50391 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.41 |
| ▸ | CCND1 | P24385 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10477477 | 0.81 | NOTUM (0.70) | NOTUMTSHRRAB9AL3MBTL1KMT2A | |
| SCHEMBL1151123 | 0.81 | NOTUM (0.70) | NOTUMTSHRRAB9AL3MBTL1KMT2A | |
| SCHEMBL931955 | 0.79 | TSHR (0.69) | NOTUMTSHRRAB9AL3MBTL1KMT2A | |
| SCHEMBL29453277 | 0.79 | TSHR (0.69) | NOTUMTSHRRAB9AL3MBTL1KMT2A | |
| SCHEMBL3649822 | 0.78 | NOTUM (0.66) | NOTUMTSHRRAB9AL3MBTL1KMT2A | |
| SCHEMBL4520021 | 0.78 | NOTUM (0.66) | NOTUMTSHRRAB9AL3MBTL1KMT2A | |
| SCHEMBL5638317 | 0.78 | NOTUM (0.66) | NOTUMTSHRRAB9AL3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL20610213 | 0.78 | TSHR (0.67) | NOTUMTSHRRAB9AL3MBTL1KMT2A | |
| SCHEMBL6628956 | 0.78 | TSHR (0.67) | NOTUMTSHRRAB9AL3MBTL1KMT2A | |
| SCHEMBL15702556 | 0.78 | NOTUM (0.66) | NOTUMTSHRRAB9AL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1088823-B1 | Fused pyrrolocarbazoles | CEPHALON INC (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-1389194-A2 | INHIBITORS OF BACE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002088101-A2 | INHIBITORS OF BACE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-11-07 | — | — | WO | disclosed |
| EP-0785938-B1 | FUSED PYRROLOCARBAZOLES | CEPHALON INC (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1088823-A1 | Fused pyrrolocarbazoles | CEPHALON, INC. (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-0885229-B1 | FUSED PYRROLO(2,3-C)CARBAZOLE-6-ONES WHICH POTENTIATE ACTIVITY OF GAMMA INTERFERON | CEPHALON INC (US) | 2000-08-02 | — | — | EP | disclosed |
| EP-0885229-A1 | FUSED PYRROLO(2,3-C)CARBAZOLE-6-ONES WHICH POTENTIATE ACTIVITY OF GAMMA INTERFERON | CEPHALON, INC. (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5801190-A | Fused pyrrolo 2,3-C! carbazole-6-ones | CEPHALON, INC. (US) | 1998-09-01 | — | — | US | disclosed |
| US-5705511-A | ENZYME INHIBITORS, ANTIINFLAMMATORY, TROPHIC FACTOR, ANTICANCER CELL GROWTH | CEPHALON, INC. (US) | 1998-01-06 | — | — | US | disclosed |
| WO-1997031002-A1 | FUSED PYRROLO(2,3-C)CARBAZOLE-6-ONES WHICH POTENTIATE ACTIVITY OF GAMMA INTERFERON | CEPHALON, INC. (US) | 1997-08-28 | — | — | WO | disclosed |
| EP-0785938-A1 | FUSED PYRROLOCARBAZOLES | CEPHALON, INC. (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5616724-A | FOR POTENTIATION OF HUMAN INTERFERON-GAMMA; IMMUNOLOGY | CEPHALON, INC. (US) | 1997-04-01 | — | — | US | disclosed |
| US-5594009-A | KINASE INHIBITORS, TROPHIC FACTOR-INDUCED ACTIVITY ENHANCEMENT, CELL SURVIVAL | CEPHALON, INC. (US) | 1997-01-14 | — | — | US | disclosed |
| US-5591855-A | KINASE INHIBITORS, TROPHIC FACTOR-INDUCED ACTIVITY ENHANCEMENT, CELL SURVIVAL | CEPHALON, INC. (US) | 1997-01-07 | — | — | US | disclosed |
| US-5475110-A | Treating nervous system disorders and inflammation, inhibiting protein and tyrosine kinases, inhibiting cell growth | CEPHALON, INC. (US) | 1995-12-12 | — | — | US | disclosed |