Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.34 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.34 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.34 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.34 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3844906 | 0.89 | KMT2A (0.39) | DGAT1CFTRDDB1CRBNHDAC1 | |
| SCHEMBL6627099 | 0.89 | NAMPT (0.40) | HDAC1HDAC2MEN1KMT2AAURKB | |
| SCHEMBL6631299 | 0.88 | ABL1 (0.40) | MEN1KMT2AAURKBGSK3B | |
| SCHEMBL6630723 | 0.86 | TDP1 (0.37) | MEN1KMT2AADCY6ADCY3ADCY9 | |
| SCHEMBL6630893 | 0.85 | MCHR1 (0.51) | MEN1KMT2A | |
| SCHEMBL6630236 | 0.85 | MCHR1 (0.46) | MEN1KMT2AAURKBCHEK1DAPK3 | |
| SCHEMBL6655582 | 0.84 | KMT2A (0.41) | MEN1KMT2AAURKBFLT3GSK3B | |
| SCHEMBL6630370 | 0.81 | KMT2A (0.41) | MEN1KMT2AAURKBFLT4KDR | |
| SCHEMBL6630581 | 0.81 | EPHX2 (0.44) | CFTRCRBNMEN1KMT2ACDK2 | |
| SCHEMBL6630566 | 0.81 | ABL1 (0.43) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379501-A1 | INDOLINONES, SUBSTITUTED IN POSITION 6, AND THEIR USE AS KINASE INHIBITORS | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002081445-A1 | INDOLINONES, SUBSTITUTED IN POSITION 6, AND THEIR USE AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |