Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.36 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.36 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.36 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.36 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.36 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.36 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.36 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6631026 | 0.93 | PAX8 (0.39) | TDP1MEN1KMT2AMAPTPOLB | |
| SCHEMBL6631299 | 0.92 | ABL1 (0.40) | MEN1KMT2AAURKBMAPK14CASP3 | |
| SCHEMBL6627099 | 0.91 | NAMPT (0.40) | TDP1MEN1KMT2AAURKBCASP3 | |
| SCHEMBL3848974 | 0.88 | KMT2A (0.41) | TDP1MEN1KMT2AMAPK14MAPT | |
| SCHEMBL6630236 | 0.87 | MCHR1 (0.46) | MEN1KMT2AAURKBMCHR1 | |
| SCHEMBL6630893 | 0.87 | MCHR1 (0.51) | TDP1MEN1KMT2APOLBMCHR1 | |
| SCHEMBL6630370 | 0.87 | KMT2A (0.41) | TDP1MEN1KMT2AAURKBCASP3 | |
| SCHEMBL6629437 | 0.86 | DGAT1 (0.38) | MEN1KMT2AADCY6ADCY3ADCY9 | |
| SCHEMBL6655582 | 0.86 | KMT2A (0.41) | TDP1MEN1KMT2AAURKBCASP3 | |
| SCHEMBL5269090 | 0.86 | BACE1 (0.41) | TDP1KMT2AAURKBMAPK14CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379501-A1 | INDOLINONES, SUBSTITUTED IN POSITION 6, AND THEIR USE AS KINASE INHIBITORS | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002081445-A1 | INDOLINONES, SUBSTITUTED IN POSITION 6, AND THEIR USE AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |