Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL425530 | 0.80 | ELANE (0.47) | ALDH1A1KMT2AELANE | |
| SCHEMBL5651399 | 0.76 | ALDH1A1 (0.53) | ALDH1A1TSHRGLAHTTMEN1 | |
| SCHEMBL380050 | 0.74 | ALDH1A1 (0.76) | ALDH1A1TSHRGLAHTTMEN1 | |
| SCHEMBL10933185 | 0.73 | ALDH1A1 (0.52) | ALDH1A1TSHRGLAHTTMEN1 | |
| Hydrochloric Acid SCHEMBL3454478 | 0.73 | ALDH1A1 (0.73) | ALDH1A1TSHRGLAHTTMEN1 | |
| SCHEMBL27811431 | 0.73 | ALDH1A1 (0.73) | ALDH1A1TSHRGLAHTTMEN1 | |
| SCHEMBL9006388 | 0.72 | ALDH1A1 (0.43) | ALDH1A1TSHRGLAHTTTP53 | |
| SCHEMBL5481370 | 0.71 | ALDH1A1 (0.70) | ALDH1A1TSHRGLAHTTMEN1 | |
| SCHEMBL10896123 | 0.71 | TSHR (0.40) | ALDH1A1TSHRGLAHTTTP53 | |
| SCHEMBL263716 | 0.70 | ALDH1A1 (1.00) | ALDH1A1TSHRGLAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |