Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 11/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 11/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | IDE | P14735 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5341200 | 0.90 | CDK5 (0.60) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5689495 | 0.83 | CDK5 (0.65) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5354931 | 0.83 | CDK5 (0.58) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5339186 | 0.83 | CDK5 (0.53) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL14558329 | 0.81 | CDK5 (0.62) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5338421 | 0.81 | CDK5 (0.61) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5341715 | 0.80 | CDK5 (0.47) | CDK5CDK5R1 | |
| SCHEMBL5343066 | 0.80 | CDK5 (0.51) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5343136 | 0.80 | CDK5 (0.66) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5342307 | 0.79 | CDK5 (0.62) | CDK5CDK5R1ROCK1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | disclosed |