Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.65 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14558392 | 0.92 | CDK5 (0.57) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL14558329 | 0.91 | CDK5 (0.62) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5338421 | 0.90 | CDK5 (0.61) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5343136 | 0.89 | CDK5 (0.66) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5341200 | 0.89 | CDK5 (0.60) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL14558375 | 0.89 | CDK5 (0.51) | CDK5CDK5R1RAB9A | |
| SCHEMBL5342307 | 0.88 | CDK5 (0.62) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5344913 | 0.88 | CDK5 (0.65) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5342467 | 0.86 | CDK5 (0.62) | CDK5CDK5R1ROCK1CCNA2CDK2 | |
| SCHEMBL5341625 | 0.85 | CDK5 (0.58) | CDK5CDK5R1ROCK1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-B1 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC (US) | 2006-03-15 | — | — | EP | claimed |
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | claimed |
| US-20020173507-A1 | Urea compounds and methods of uses | AMGEN INC. | 2002-11-21 | — | — | US | claimed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | claimed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1309589-B1 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC (US) | 2006-03-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173507-A1 | Urea compounds and methods of uses | SLC14A1, UMPS, BAX | CDK5 40/4885CDK5R1 244/4885ROCK1 3616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.