Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 9/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.60 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.59 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.56 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.55 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.55 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.55 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14967208 | 0.86 | LPAR1 (0.72) | PARP10MAPK14PARP15GAAPOLB | |
| SCHEMBL14018654 | 0.85 | PARP10 (0.56) | PARP10MAPK14PARP15PARP2GAA | |
| SCHEMBL11498069 | 0.83 | PARP10 (0.77) | PARP10PARP15PARP2POLBCYP3A4 | |
| SCHEMBL8560809 | 0.82 | POLB (0.65) | MAPK14GAAPOLBLPAR1LPAR5 | |
| SCHEMBL3421693 | 0.81 | POLB (0.79) | MAPK14GAAPOLBLPAR1LPAR5 | |
| SCHEMBL6044963 | 0.81 | PARP10 (0.57) | PARP10MAPK14PARP15PARP2LPAR1 | |
| SCHEMBL18609418 | 0.79 | MAPK14 (0.57) | MAPK14GAAPOLBLPAR1LPAR5 | |
| SCHEMBL28550648 | 0.78 | POLB (0.69) | MAPK14GAAPOLBLPAR1LPAR5 | |
| SCHEMBL27868427 | 0.78 | GAA (0.69) | MAPK14GAAPOLBLPAR1LPAR5 | |
| SCHEMBL23657704 | 0.78 | PARP1 (0.65) | PARP10GAAALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |