Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.54 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27860600 | 0.87 | POLB (0.49) | POLBGAAMAPK14CYP3A4EZH2 | |
| SCHEMBL18610115 | 0.86 | POLB (0.54) | POLBGAAMAPK14CYP3A4EZH2 | |
| SCHEMBL16507214 | 0.85 | LPAR1 (0.80) | MAPK14LPAR1LPAR5 | |
| SCHEMBL18609418 | 0.85 | MAPK14 (0.57) | POLBGAAMAPK14CYP3A4EZH2 | |
| SCHEMBL11411879 | 0.84 | CA1 (0.62) | POLBGAARAB9ANPC1LPAR1 | |
| SCHEMBL25311656 | 0.84 | CA1 (0.50) | POLBGAAMAPK14RAB9ANPC1 | |
| SCHEMBL14967208 | 0.83 | LPAR1 (0.72) | POLBGAAMAPK14CYP3A4EZH2 | |
| SCHEMBL6629977 | 0.82 | PARP10 (0.60) | POLBGAAMAPK14CYP3A4EZH2 | |
| SCHEMBL9242685 | 0.81 | RAB9A (0.65) | GAARAB9ANPC1LPAR1LPAR5 | |
| SCHEMBL680151 | 0.80 | MAPK14 (0.61) | POLBGAAMAPK14CYP3A4EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |