Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | STAT1 | P42224 | 1/20 | 0.64 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632377 | 0.89 | NPC1 (0.70) | NPC1ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL7122333 | 0.85 | NPC1 (0.68) | NPC1ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL6630357 | 0.82 | PDK1 (0.59) | NPC1ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL7912467 | 0.81 | KDM4E (0.73) | NPC1ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL6631563 | 0.77 | KDM4E (0.52) | NPC1ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL1608015 | 0.77 | ERAP1 (1.00) | NPC1ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL7123957 | 0.77 | NPC1 (0.80) | NPC1ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL4449250 | 0.76 | ERAP1 (0.68) | NPC1ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL5650933 | 0.76 | KMT2A (0.62) | NPC1ALDH1A1KDM4ERAB9AKMT2A | |
| SCHEMBL7120381 | 0.75 | ABCB1 (0.59) | NPC1ALDH1A1KDM4ERAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | claimed |