Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL943141 | 0.71 | GAA (0.46) | BRD4CREBBPALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL13323 | 0.71 | ALDH1A1 (0.60) | BRD4CREBBPALDH1A1TSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30648399 | 0.69 | ALDH1A1 (0.58) | BRD4CREBBPALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL155144 | 0.68 | GAA (0.48) | BRD4CREBBPALDH1A1SMN1; SMN2GAA | |
| SCHEMBL1756087 | 0.68 | HDAC1 (0.51) | BRD4CREBBPALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8853727 | 0.68 | GAA (0.54) | BRD4CREBBPALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL1973489 | 0.67 | AHR (0.45) | BRD4CREBBPALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL2828423 | 0.67 | GAA (0.52) | ALDH1A1SMN1; SMN2GAAMEN1KMT2A | |
| SCHEMBL9628939 | 0.67 | NPC1 (0.53) | BRD4CREBBPALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL1913191 | 0.67 | BRD4 (0.47) | BRD4CREBBPALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317459-B1 | BICYCLIC PYRROLYL AMIDES AS GLUCOGEN PHOSPHORYLASE INHIBITORS | ASTRAZENECA AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| EP-1317459-A1 | BICYCLIC PYRROLYL AMIDES AS GLUCOGEN PHOSPHORYLASE INHIBITORS | AstraZeneca AB (SE) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020530-A1 | BICYCLIC PYRROLYL AMIDES AS GLUCOGEN PHOSPHORYLASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-03-14 | — | — | WO | disclosed |