Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 4/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5403125 | 0.91 | MAPK10 (0.41) | MEN1KMT2APDE1APDE1BPDE1C | |
| SCHEMBL5398457 | 0.86 | HIF1A (0.43) | MEN1KMT2APDE1APDE1BPDE1C | |
| SCHEMBL5407645 | 0.83 | SLC16A1 (0.47) | MEN1KMT2APDE1APDE1BPDE1C | |
| SCHEMBL5407969 | 0.83 | SLC22A12 (0.46) | MEN1KMT2APDE1APDE1BPDE1C | |
| SCHEMBL5404206 | 0.83 | MEN1 (0.42) | MEN1KMT2APDE1APDE1BPDE1C | |
| SCHEMBL5398859 | 0.81 | SLC16A1 (0.45) | — | |
| SCHEMBL5400132 | 0.81 | MAPK8 (0.44) | MEN1KMT2APDE1APDE1BPDE1C | |
| SCHEMBL5393473 | 0.81 | KMT2A (0.40) | MEN1KMT2APDE1APDE1BPDE1C | |
| SCHEMBL5407705 | 0.81 | DPP4 (0.40) | MEN1KMT2APDE1APDE1BPDE1C | |
| SCHEMBL5417969 | 0.80 | MEN1 (0.39) | MEN1KMT2APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412355-A1 | NEW PYRAZOLO(3,4-D)PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | AstraZeneca AB (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002567-A1 | NEW PYRAZOLO[3,4-D]PYRIMIDINES INHIBITING H. PYLORI INFECTIONS | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | WO | disclosed |