Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | FAAH | O00519 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | LSS | P48449 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2232123 | 0.93 | POLB (0.61) | SIGMAR1POLBPKMFAAHALDH1A1 | |
| SCHEMBL13582238 | 0.92 | HRH3 (0.73) | SIGMAR1POLBPKMFAAHALDH1A1 | |
| SCHEMBL2232052 | 0.89 | POLB (0.57) | SIGMAR1POLBPKMFAAHALDH1A1 | |
| SCHEMBL2232206 | 0.89 | POLB (0.57) | SIGMAR1POLBPKMFAAHALDH1A1 | |
| SCHEMBL27856022 | 0.89 | POLB (0.70) | SIGMAR1POLBPKMFAAHALDH1A1 | |
| SCHEMBL19049377 | 0.88 | HRH3 (0.71) | SIGMAR1POLBPKMFAAHALDH1A1 | |
| SCHEMBL19002261 | 0.85 | POLB (0.73) | SIGMAR1POLBPKMFAAHALDH1A1 | |
| SCHEMBL19285228 | 0.85 | SIGMAR1 (0.85) | SIGMAR1POLBPKMALDH1A1LMNA | |
| SCHEMBL1043952 | 0.85 | SIGMAR1 (0.85) | SIGMAR1POLBPKMALDH1A1LMNA | |
| SCHEMBL20804352 | 0.85 | SIGMAR1 (0.85) | SIGMAR1POLBPKMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2800565-B1 | CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME | LUNDBECK LA JOLLA RESEARCH CENTER INC (US) | 2020-03-25 | — | — | EP | claimed |
| CN-1602191-A | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2005-03-30 | — | — | CN | claimed |
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | claimed |
| US-20240287094-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINES | JIANGSU HENGRUI PHARMACEUTICALS CO., LTD. (CN) | 2024-08-29 | — | — | US | disclosed |
| EP-4349836-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINES | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2024-04-10 | — | — | EP | disclosed |
| CN-1326519-C | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2007-07-18 | — | — | CN | disclosed |
| CN-1602191-A | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2005-03-30 | — | — | CN | disclosed |
| US-4562189-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1985-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287094-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINES | PARP1, PARP11, PARP8 | SIGMAR1 4335/4885POLB 292/4885PKM 311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.