Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 16/20 | 0.58 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.58 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.58 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.58 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.58 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6631259 | 0.83 | PARP10 (0.64) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL6633394 | 0.80 | PARP10 (0.58) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL4964075 | 0.78 | PARP10 (0.57) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL3137816 | 0.75 | PARP10 (1.00) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL24592196 | 0.74 | PARP10 (0.79) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL3013339 | 0.74 | PARP10 (0.79) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL6631091 | 0.72 | PARP10 (0.62) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL5697485 | 0.72 | LTA4H (0.46) | — | |
| SCHEMBL6630663 | 0.71 | PARP10 (0.79) | PARP10PARP15PARP4PARP14ALDH1A1 | |
| SCHEMBL25352415 | 0.71 | DAO (0.42) | ALDH1A1KMT2ASENP8SENP6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1248787-B1 | NOVEL SUBTITUTED PYRAZOLO[4,3-e]DIAZEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE AS MEDICINAL PRODUCTS AND PROCESSES FOR PREPARING THEM | WARNER LAMBERT CO (US) | 2004-10-06 | — | — | EP | claimed |
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |