Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 9/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141164 | 0.85 | LMNA (0.63) | KMT2AMEN1MAOBCYP1A2NPC1 | |
| SCHEMBL30239922 | 0.85 | LMNA (0.63) | KMT2AMEN1MAOBCYP1A2NPC1 | |
| SCHEMBL28870970 | 0.85 | MEN1 (0.73) | KMT2AMEN1PARP1CES2CES1 | |
| SCHEMBL28405031 | 0.83 | MEN1 (0.59) | KMT2AMEN1PARP1NPC1ALDH1A1 | |
| SCHEMBL3131557 | 0.82 | LMNA (0.61) | KMT2AMEN1CYP1A2 | |
| SCHEMBL28284714 | 0.81 | MEN1 (0.61) | KMT2AMEN1PARP1ALDH1A1CES2 | |
| SCHEMBL25620248 | 0.80 | MEN1 (0.71) | KMT2AMEN1MAOBCYP1A2NPC1 | |
| SCHEMBL26802232 | 0.80 | NPC1 (0.56) | KMT2AMEN1PARP1MAOBCYP1A2 | |
| SCHEMBL2567322 | 0.80 | MAOB (0.59) | KMT2AMEN1MAOBCYP1A2ALDH1A1 | |
| SCHEMBL17785162 | 0.80 | KMT2A (0.49) | KMT2AMEN1PARP1MAOBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111836801-B | Compounds for inhibiting TNIK and medical use thereof | 韩国化学硏究院 | 2024-02-02 | — | — | CN | disclosed |
| CN-110423212-B | Hydroxy indole carboxylic acid-based inhibitors of SHP2 | 美国印第安纳大学研究和技术公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-108929263-B | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-07-22 | — | — | CN | disclosed |
| CN-114450271-A | Ureas, amino and substituted heteroaryl compounds for Cbl-b inhibition | 纽力克斯治疗公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-111836801-A | Compound for inhibiting TNIK and medical application thereof | 韩国化学硏究院 | 2020-10-27 | — | — | CN | disclosed |
| CN-111108092-A | Arylamide Kv2.1 inhibitor and preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2020-05-05 | — | — | CN | disclosed |
| CN-110668976-A | Rivastigmine optical isomeric intermediate and synthetic method of (R) -rivastigmine | 山东师范大学 | 2020-01-10 | — | — | CN | disclosed |
| CN-108822000-A | A kind of method of reduction amination synthesis (S)-Rivastigmine | 山东师范大学 | 2018-11-16 | — | — | CN | disclosed |
| CN-104860890-A | T790M mutant epidermal growth factor receptor (EGFR) inhibitor and application of same in preparation of antitumor drugs | PHARMARESOURCES SHANGHAI CO LTD | 2015-08-26 | — | — | CN | disclosed |
| EP-1458375-A2 | COMPOSITIONS FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051842-A2 | COMPOSITIONS DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |