Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.61 |
| ▸ | HPGDS | O60760 | 3/20 | 0.55 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100884 | 1.00 | CHRNA7 (0.61) | CHRNA7HPGDSSMYD3DRD4MCHR1 | |
| SCHEMBL6100875 | 1.00 | CHRNA7 (0.61) | CHRNA7HPGDSSMYD3DRD4MCHR1 | |
| SCHEMBL6099719 | 0.94 | HPGDS (0.56) | CHRNA7HPGDSSMYD3DRD4MCHR1 | |
| SCHEMBL6098251 | 0.86 | CHRNA7 (0.68) | CHRNA7DRD4 | |
| SCHEMBL6098257 | 0.86 | CHRNA7 (0.68) | CHRNA7DRD4 | |
| SCHEMBL6303017 | 0.84 | CHRNA7 (0.66) | CHRNA7 | |
| SCHEMBL6303021 | 0.84 | CHRNA7 (0.66) | CHRNA7 | |
| SCHEMBL6100994 | 0.84 | CHRNA7 (0.65) | CHRNA7DRD4MCHR1 | |
| SCHEMBL6100991 | 0.84 | CHRNA7 (0.65) | CHRNA7DRD4MCHR1 | |
| SCHEMBL6098389 | 0.83 | CHRNA7 (0.64) | CHRNA7HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478646-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003072578-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |