Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 7/20 | 0.59 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.35 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100771 | 1.00 | CHRNA7 (0.59) | CHRNA7CNR1HSD11B1PRKAA2GRM5 | |
| SCHEMBL6100767 | 1.00 | CHRNA7 (0.59) | CHRNA7CNR1HSD11B1PRKAA2GRM5 | |
| SCHEMBL6100500 | 0.94 | CHRNA7 (0.51) | CHRNA7HSD11B1PRKAA2GRM5MLLT3 | |
| SCHEMBL6100835 | 0.87 | CHRNA7 (0.61) | CHRNA7CNR1HSD11B1PRKAA2GRM5 | |
| SCHEMBL6100828 | 0.87 | CHRNA7 (0.61) | CHRNA7CNR1HSD11B1PRKAA2GRM5 | |
| SCHEMBL6635518 | 0.86 | CHRNA7 (0.59) | CHRNA7CNR1HSD11B1PRKAA2GRM5 | |
| SCHEMBL6098653 | 0.86 | CHRNA7 (0.59) | CHRNA7CNR1HSD11B1PRKAA2GRM5 | |
| SCHEMBL6098659 | 0.86 | CHRNA7 (0.59) | CHRNA7CNR1HSD11B1PRKAA2GRM5 | |
| SCHEMBL6098953 | 0.84 | CHRNA7 (0.55) | CHRNA7PRKAA2 | |
| SCHEMBL6101356 | 0.84 | CHRNA7 (0.55) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478646-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003072578-A1 | AZABICYCLIC COMPOUNDS WITH ALFA7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-09-04 | — | — | WO | disclosed |